Degradable Dextran Nanopolymer as a Carrier for Choline Kinase (ChoK) siRNA Cancer Therapy
نویسندگان
چکیده
منابع مشابه
Degradable Dextran Nanopolymer as a Carrier for Choline Kinase (ChoK) siRNA Cancer Therapy
Although small interfering RNA (siRNA) therapy has proven to be a specific and effective treatment in cells, the delivery of siRNA is a challenge for the applications of siRNA therapy. We present a degradable dextran with amine groups as an siRNA nano-carrier. In our nano-carrier, the amine groups are conjugated to the dextran platform through the acetal bonds, which are acid sensitive. Therefo...
متن کاملAcid-degradable Dextran as an Image Guided siRNA Carrier for COX-2 Downregulation
Purpose: Effective in vivo delivery of siRNA to silence genes is a highly sought-after goal in the treatment of multiple diseases. Cyclooxygenase-2 (COX-2) is a major mediator of inflammation and its effective and specific downregulation has been of major interest to treat conditions ranging from auto-immune diseases to gastric inflammation and cancer. Here we developed a novel and efficient me...
متن کاملCholine kinase as a precision medicine target for therapy in cancer, autoimmune diseases and malaria
Cancer cells have an altered metabolism that provides advantages to support unregulated growth and higher duplication rates. Among these critical changes, energy generation through aerobic glycolysis as well as increased glutamine catabolism, are essential components associated with altered levels of specific metabolites. Up-regulation of lipid metabolism also occurs frequently in cancer cells....
متن کاملPolyacylurethanes as Novel Degradable Cell Carrier Materials for Tissue Engineering
Polycaprolactone (PCL) polyester and segmented aliphatic polyester urethanes based on PCL soft segment have been thoroughly investigated as biodegradable scaffolds for tissue engineering. Although proven beneficial as long term implants, these materials degrade very slowly and are therefore not suitable in applications in which scaffold support is needed for a shorter time. A recently developed...
متن کاملCholine kinase as a link connecting phospholipid metabolism and cell cycle regulation: implications in cancer therapy.
Choline kinase alpha (ChoKalpha) is an enzyme involved in the metabolism of phospholipids recently found to play a relevant role in the regulation of cell proliferation, oncogenic transformation and human carcinogenesis. In addition, this novel oncogene has been recently defined as a prognostic factor in human cancer, and as a promising target for therapy since its specific inhibitors display e...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Nanomaterials
سال: 2016
ISSN: 2079-4991
DOI: 10.3390/nano6020034